About El Camino HealthĮl Camino Health has served the communities of Santa Clara County for more than 60 years, with nationally recognized physicians and nurses at two not-for-profit acute care hospitals in Los Gatos and Mountain View, and primary care, multi-specialty care, and urgent care locations across the region. The World's Best Hospitals 2023 recognizes the best medical institutions across 28 countries: USA, Germany, Japan, South Korea, France, Italy, United Kingdom, Spain, Brazil, Canada, India, Australia, Mexico, The Netherlands, Austria, Thailand, Switzerland, Sweden, Belgium, Finland, Norway, Denmark, Israel, Singapore, United Arab Emirates, Colombia, Saudi Arabia, and Taiwan. ![]() Hospital Quality Metrics: patient safety, hygiene measures, waiting times and quality of treatment. ![]() Patient Reported Outcome Measures: surveys measuring patient satisfaction with hospitals.Patient Experience: survey of patient satisfaction with hospitalization.Hospital recommendations from Medical Experts: an international online survey sent to more than 80,000 healthcare professionals.Four data sources were used for the evaluation: Newsweek and Statista developed a complex methodology to ensure the quality and validity of the ranking. ![]() "These rankings help guide Newsweek readers in making crucial decisions about care for themselves and their loved ones." "The 2023 rankings are based on a global survey of doctors, healthcare professionals, and administrators across four continents," said Nancy Cooper, global editor-in-chief at Newsweek. With more women and families choosing to deliver at El Camino Health that any other hospital in the Bay area, our facilities are consistently recognized at the local and national level as one of the best hospitals to have a baby. The Taft Center for Clinical Research, located on-site, was the first in the world to enroll a patient in a study for the intravenous precursor to Paxlovid, the first oral antiviral COVID-19 treatment approved by the Food and Drug Administration. The hospital is currently a showcase site for an advanced radiation oncology technology that uses artificial intelligence to create customized cancer-fighting treatment plans in minutes. Since opening its doors to the Mountain View hospital in 1961, El Camino Health has embraced a culture of innovation, and has provided an environment for advanced clinical studies. I am proud of our history and achievements in advancing the science of medicine." "The clinical research and innovations that come out of our hospital have changed lives and improved patient outcomes throughout our region and well beyond. "This award personifies the dedication and effort of all of our employees, and their continued commitment toward delivering the best care in the Bay Area," said Dan Woods, CEO of El Camino Health. The 2023 awards list was announced on March 1 and can currently be viewed on Newsweek's website. This prestigious award is presented by Newsweek and Statista Inc., the world's leading statistics portal and industry ranking provider. 2495 Hospital Drive will be on your left.Mountain View, CA – El Camino Health's Mountain View hospital has been named one of the World's Best Hospitals by Newsweek for the second year in a row. Take exit 22A toward El Camino Real/Mountain View/CA-82N. 2495 Hospital Drive will be on your left. Take the Fremont Avenue exit toward Los Altos. Use the right 2 lanes to take the CA-85 N exit toward Mountain View. Keep right at the fork, follow signs for El Monte Rd. Keep left at the fork follow signs for El Monte Road E. Take exit 16 for El Monte Rd toward Moody Rd. Take exit 398B for CA-85 S toward Santa Cruz/Cupertino.
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Your antivirus may detect the Goldie: Scheduling app as malware as malware if the download link to com.appointfix is broken. We have already checked if the download link is safe, however for your own protection we recommend that you scan the downloaded app with your antivirus. The app is listed on our website since and was downloaded 15 times. ![]() To install Goldie: Scheduling app on your Android device, just click the green Continue To App button above to start the installation process. The latest version released by its developer is 15.2.0. The company that develops Goldie: Scheduling app is Quartet. Goldie: Scheduling app is a free app for Android published in the PIMS & Calendars list of apps, part of Business. ![]() Goldie is popular with hairstylist, salons, barbershops, lash and makeup artists, estheticians, tattoo parlors, pet groomers, massage therapists, car detailers, and many more professionals who want to book appointments with ease. Simplify your daily planner and schedule appointments like a pro with Goldie, the appointment manager. Team management: Add your staff, grant unique permissions, and effectively organize your team in one place.Team - Starting at $29.99/month - Appointments manager and scheduling for teams: Multiple message templates: Set up templates to send clients personalized automatic messages such as booking confirmations, appointment reminders, and follow-ups.Advanced revenue reports: Break down appointments by service or client to identify opportunities to increase your earnings.Complex appointments: Set up repeating appointments or add more clients to an appointment.Payments: Your clients can securely pay online or in person with tap to pay.Appointment deposits: Require a deposit when clients book online to eliminate no-shows.Pro plan - $19.99/month - All the tools you need to grow appointments and manage your business. Basic revenue reports: See your earnings and your top-performing services and clients.Sync with Apple and Google Calendars: Consolidate all your personal and business appointments in one place.Your appointment scheduler has never been more accessible. Calendar planner: Effortlessly flip through your appointment calendar views.Or send your clients mass promotional texts! Marketing messages: Send appointment rebooking reminders to clients.Service offerings: Define and personalize your service offerings for client appointments.Impress and inform potential clients with a professional online presence. ![]()
![]() FlowXO comes with a level of artificial intelligence that would have been unthinkable just a few years ago. In the right hands, FlowXO can serve as the foundation for a simple chat bot to a fully human-bot hybrid. Simple scenarios can be transferred into advanced sequences of dialogue that look and feel more like human-to-human contact than ever before.įlowXO is a tool that has already created bots for popular platforms like Slack. Both developers and non-developers can create a perfectly passable bot using MEOKAY. MEOKAY specializes in helping businesses to create conversational bots. MEOKAYĬonversation is essential to making a bot work. A Telegram Bot can send customized reminders, notifications, and other alerts. Anyone can use their code to create chatbots of their own, which means the API used by Telegram can also be used. It can also be used to create a chatbot because Telegram made their code available to the open source community. You do not need to write any code and the best part is it’s completely free. It’s easy to integrate any bot you create with this tool with popular eCommerce platforms like Shopify. It’s one of the simplest platforms on the market today. ![]() With this tool, you’ll be able to respond to customers without the need for any complex coding. Regular users of Facebook should consider utilizing ChattyPeople to communicate with their customers. These ten tools will enable you to create your own chatbot. They’re also useful for answering simple questions.īuilding a chatbot doesn’t have to be rocket science. An automated chatbot makes customers feel as if someone is always there and that their needs are being considered. The problem is that you can’t be available personally every hour of every day. Reliable Support: Lastly, a good chatbot builder should provide reliable customer support to address any issues or concerns promptly.Interacting with your customers and keeping them happy is vital to any good business.The platform should offer flexible plans and options to accommodate your growing needs. Scalability: As your business grows, your chatbot should be able to scale with it.Analytics and Reporting: A robust chatbot builder should provide comprehensive analytics and reporting features, helping businesses track chatbot performance and gain valuable insights into customer behavior.Integration Capabilities: The platform should provide seamless integration with popular platforms and services, such as social media channels, messaging apps, CRM systems, and more.Customization Features: A great chatbot builder should offer a wide range of customization options, allowing businesses to tailor their chatbots according to their specific needs.AI and NLP Capabilities: The platform should use advanced AI and Natural Language Processing (NLP) technologies to understand and respond to user queries effectively.Ease of Use: The platform should offer a user-friendly interface, allowing even non-technical users to create chatbots without any coding knowledge. ![]() Here are some key characteristics to look for: It should offer a comprehensive set of tools to design, build, and manage chatbots effectively. A top-notch AI chatbot builder needs to be intuitive, feature-rich, and flexible. ![]() You can select between ‘All/ #/ When the tags are fetched automatically, it’ll fetch them according to this settings. You can choose which type of tags you’ll use by changing option ‘Tag: Type’. Tags that show on ‘Prompt: Tags’ and sort options can be set inside settings. Add will simply add the tag you selected. Switch will remove previous tag if it exists. ‘Prompt: Tags’ have 2 types which are Switch and Add. You can type in ‘#tag1 #tag2’ in ‘Tag’ type to put in multiple tags at once if needed. ‘Switch’ type lets you switch between multiple tags including an empty tag. ‘Tag’ type lets you add/remove tag at one touch. Additionally you can use ‘Prompt: Tags’ to select from preset tags. Inside ‘Settings > Quick Actions’, you can use ‘Tag’ type and ‘Switch’ type to manage tags. First set your preferred option on ‘Settings > General > Tag on’ to choose where your tags should be at. ![]() To add/remove tags easily on tasks, you can use Quick Actions. It’s flexible and powerful Tags on Quick Actions Or you can show tasks that include both #work and #today. For example, you can make a list that shows tasks with #later tag and hide tasks with #hide tag. Select ‘Include’ and type in whatever tag you’d like below (i.e #tag, can use multiple filters to include or exclude multiple tags on Smart List for powerful use. While adding a new Smart List, add a ‘Filter’ with type ‘Text’. The key is on Smart Lists and Quick Actions. – Font size and Board related settings will not be synced.On GoodTask, you can use tags with any symbol and any text. – ‘Drag and Drop’ options will not be synced. Theme option syncs user-generated custom themes. – Selected theme settings are not synced. – ‘Notifications’ settings including ‘Auto-Snooze’ settings will not be synced. NOTE: Some preferences that may need different settings per device will not be synced with Automatic Preferences Sync. (You can turn off and then turn back on to see the option too)Īfter that, all will follow that preferences. So once you have preferences perfectly set on one device, you may turn the option on and upload that one. – GoodTask related features such as ‘Repeat after completion’, ‘Manual Sort’, ‘Auto-Snooze’ are synced in same way. – If you edit files directly, you need to change or remove date field to make the app refresh. Auto Preferences Sync and manual upload/download will run for the selected parts only. – You can select parts to include in sync process. – If anything uploaded changes on other device, it downloads automatically. – If you change any preferences, it uploads automatically to replace current uploaded version. – When you turn it on, you can choose to download the one uploaded or upload current one. You can manually upload or download by simply choosing the option. If you choose ‘Download’, it’ll download the settings that’s uploaded in the cloud. Then settings on this device will be uploaded. If you want to keep the settings on current device, choose ‘Use Current’. When you turn it on, it’ll ask you to choose between download or use current. – Inside default Settings.app > iCloud, make sure iCloud Drive is turned on – Turn on ‘GoodTask > Settings > iCloud Sync > Automatic Preferences Sync’ – Inside ‘ > System Preferences > iCloud’, make sure iCloud Drive is turned on – Turn on ‘GoodTask > Preferences > Sync > Automatic Preferences Sync’ Check below to sync your preferences including Smart Lists and Quick Actions. From version 5.4, GoodTask uses files in iCloud Drive to save and sync. Your preferences can be automatically synced including Smart Lists and Quick Actions. – ‘Settings.app > Accounts & Passwords’ Automatic Preferences Sync – ‘Settings.app > Account (that show your name on top) > iCloud’ – ‘Reminders.app > Menu bar > Reminders > Accounts…’ ![]() ![]() If you use iCloud Reminders lists or other services such as Outlook, your data will be synced automatically with the devices that use same account. GoodTask uses and shares default Apple’s Reminders app’s data. ![]() “We've got a lot of young guys.”Įmanuel Wilson ran for two touchdowns, including a breakaway 80-yarder, for Green Bay.īurrow suffered the calf strain early in camp. “I think a game like this, everybody's able to get reps, get in there, get a feel for the game," Love said. Green Bay's quarterbacks distributed passes to 14 receivers who are hoping to be part of a new-look offense, which also lost last year's leading receiver, Allen Lazard, and its top two tight ends. He directed three touchdown drives but was also intercepted twice by Bengals safety Tycen Anderson, who brought the first one back 43 yards for the Bengals' only TD of the game.Ĭlifford finished 20 for 26 for 208 yards and a touchdown pass to tight end Tyler Davis. I thought it was really good first exposure for him for the season.”Ĭlifford, a rookie out of Penn State, got most of the playing time for Green Bay after Love took a seat. I thought we were getting in and out of the huddle quickly. "A lot of good came out of it, just the poise he showed, the command he showed. ![]() “There's a lot to learn from it," Packers coach Matt LeFleur said. Love - also impressive in a joint practice with the Bengals on Wednesday - spent three seasons as the backup to the four-time MVP Rodgers, who was traded to the New York Jets. “I think the passing game was in stride,” Love said.įor the Bengals, Joe Burrow sat out with a calf strain - he likely wouldn’t have played anyway - as Jake Browning and Trevor Siemian split the reps at quarterback. ![]() He completed 7 of 10 passes for 46 yards and a lofted a perfect throw to Romeo Doubs for a 9-yard touchdown. Love, the replacement for Aaron Rodgers, played only part of the first quarter but was in command as the Packers went on to beat the Bengals 36-19 in the teams' preseason opener Friday night. NFL, Cincinnati Bengals, Green Bay PackersĬINCINNATI - Jordan Love and Sean Clifford showed they can both move the Green Bay Packers' offense, at least in an early test against a leaky Cincinnati Bengals defense with few starters on the field. Winning it didn’t get us anything, it was just fun to watch.Love, Clifford help Packers roll past Bengals in preseason opener. Kinda like when this happened: A smile worth a thousand words! The Bengals are going to lose more than they win, but in a game in which they’re expected to lose, they will rock out, and we’re going to have a lot of fun watching them spoil the end of the season for someone else. ![]() Also, if the Bengals do lose every game, they’ll have a top-10 pick, and the last time you gave Joe Burrow a top-10 pick, it ended up being Ja’Marr Chase, and the Bengals went to the Super Bowl. As a fan, winning is a little more fun when your team is the underdog. Obviously, there are upsides to being the underdog. The Bengals face the Colts next week in Cincinnati, and they play the Browns in Week 18, also at home. The two closest teams to them, according to ESPN, are the Colts (6-5) and the Browns (7-4). Without Burrow and with a defense that can struggle to get off the field at times, ESPN has the Bengals sitting 22nd in the NFL, which is behind every team they play to close out the season. The Bengals being the underdog will likely be a common theme for the rest of the season, based on ESPN’s Football Power Index. They sit at 5-6 heading into a Week 13 Monday Night Football matchup against the Jacksonville Jaguars, who are favored by more than a touchdown. The defense doesn’t have the same bite it had over the last couple of years.Īll of these single turds have merged and congealed into the massive sewer clog that is the 2023 Cincinnati Bengals season. ![]() Our third-party vendor uses a national criminal database ("NCD") to screen service professionals. We use a third-party vendor to conduct a criminal records search in the county in which the business owner or principal works. As always, we recommend that you conduct your own research on the businesses you hire, including making inquiries directly with the businesses regarding their employee background check policies. Unfortunately, we cannot perform a background check on every employee of a business-the background checks are performed only on the owner or principal. The owner or principal of each business in HomeAdvisor's network (with the exception of Corporate Accounts) must pass a background check. Winterize or Activate a Sprinkler SystemĬriminal Background Check Who does HomeAdvisor background check?.Treat, Protect and Maintain Trees & Shrubs.Service a Lawn and Garden Sprinkler System.Repair Traditional Vinyl or Linoleum Flooring.Repair or Resurface Concrete Driveways, Patios, Walks & Floors.Repair or Partially Replace Wood Flooring.Repair or Partially Replace a Wood Fence.Repair or Partially Replace a PVC or Plastic Fence.Repair or Partially Replace an Aluminum or Steel Fence.Repair Landscape Lighting or Outdoor Lighting.Repair Interior Trim and Decorative Moldings.Level Concrete Slabs Using Injection Technology.Install Traditional Vinyl or Linoleum Flooring.Install Synthetic Grass for Landscaping, Putting Greens, Play Areas, etc. ![]() Install Roof Heating Cable to Melt Snow.Install, Replace or Repair a Main Water Pipe.Install, Replace or Repair a Main Sewer Pipe.Install, Repair or Replace Plumbing or Fixtures.Install Plumbing in a Remodel or Addition.Install or Replace Wood Stairs and Railings.Install or Replace Wood Shake or Composite Roofing.Install or Replace Traditional Tile Roofing.Install or Replace Natural Slate Roofing.Install or Replace Exterior Window Shutters.Install or Replace a Vinyl or PVC Fence.Install or Replace an Asphalt Shingle Roof.Install or Replace an Aluminum or Steel Fence.Install or Replace a Flat, Foam or Single Ply Roof.Install or Completely Replace Wood Flooring.Install Interlocking Pavers for Patios, Walks and Steps.Install Interlocking Pavers for Driveways & Floors.Install Interior Trim and Decorative Moldings.Install Interior Foundation Drains or Sump Pump.Install Electrical Switches, Outlets, and Fixtures.Install Electrical for a Home Addition or Remodel.Install Concrete Patios, Walks and Steps.Install a Lawn and Garden Sprinkler System.Grade or Reslope Grounds for Landscaping.Clean, Grout, Polish and Maintain Tile, Stone, or Marble.Camera Locate Breakage for a Plumbing System.Build a Custom Arbor, Pergola or Trellis.Apply concrete finish, overlay, or coloring to existing concrete. ![]() How long does a BMW iDrive software update take? Without a clear goal in mind or a specific problem that needs fixing, your BMW will almost never need a software update. It may also be the solution when running into compatibility issues with third-party hardware that isn't designed to work with older iDrive software versions. For example, if you want to activate a specific feature (like full-screen mode for Apple CarPlay), but it isn't supported by your vehicle's current software version, updating your software could be the answer. Updating your iDrive software is only required in a limited range of situations. How do I know if my BMW needs an iDrive software update? With that in mind, be sure to get in touch with us before ordering to discuss whether an iDrive software update is suitable for your needs. Please note that iDrive software updates of this kind are not advised unless necessary to solve specific problems, and are not required as part of routine maintenance of your vehicle. Same goes for MINI Connected system, if you wish to update it our MINI software update will bring a complete overhaul to your infotainment features – greater menu customization, clearer navigation, full screen Apple CarPlay and improved digital services. Our BMW iDrive software update lets you individually update the software of your iDrive, letting you solve compatibility or other issues. Just connect with our expert technician over the internet, and all the hard work will be done for you. What's more, our innovative remote process means you won't even need to leave home. At BimmerTech, we offer iDrive software updates for a range of situations. When it comes to updating your car's software, most people are looking at getting more from the iDrive infotainment system. But even older models can be retrofitted with iDrive (at ) and Combox (check out the BimmerTech Combox Retrofit Kit ), adding greater multimedia capabilities. Newer NBT and later iDrive systems have Combox functionality built-in, making things even easier. Any owner can install this kind of update themselves as long as their car features a Combox, which works with iDrive and enhances many technology features in your BMW. This may cover things like multimedia, Bluetooth, Internet connectivity, or mobile compatibility with the latest version of Apple iOS or Samsung/Android system. We strongly advise not to do it without a justifiable reason.īMW ConnectedDrive software update, or media software update. The update is performed by BimmerTech technician via a remote coding session and takes up to 1h. It is needed when installing some new software or hardware which is only supposed to work with the latest software versions. There are basically two kinds of BMW iDrive software updates.īimmerTech iDrive software update is an update that upgrades the software version (i-Level) of your iDrive system. Let’s give you a quick rundown on how it works. For more help updating your BMW's software, please contact your BMW dealer directly.īimmerTech iDrive software update vs. ![]() PLEASE NOTE: BimmerTech is not able to offer support for software updates provided by BMW or any other company. ![]() The big questions are: How to update BMW software? How do you find out about them? What is the latest bmw software version? How do you know if they are for your model BMW? And more importantly, can you install the updates on your own or do you have to go to your dealer? To make sure your vehicle doesn’t slip behind everything else you’re using, BMW regularly releases new software updates, improving multimedia support and compatibility with a wide range of popular mobile devices. Keeping a car - which could still be in production a decade after launch - up-to-date with the shifting tech landscape doesn’t come easy. Technology moves quickly every year there comes a wave of new phones and laptops packing the latest features, and dropping features that used to be commonplace. ![]() The blade moves vertically in and out of the handle. To find out more about the incredible selection of OTF knives we have available, contact eKnives at (423)-525-9477 to speak with our knowledgeable staff about which OTF knife would be the perfect addition to your knife collection.Out the front (OTF) knives are a subset of automatic knives. Final ThoughtsĪn OTF knife is a must-have for any knife enthusiast’s collection, and these brands offer a range of superior quality knives that are perfect for EDC, as well as for displaying in your carefully curated knife collection. ![]() The easy-to-use slide allows for fast, responsive tactical deployment, and the sturdy Elmax steel holds its edge like no other knife on the market. And the mechanism is offset from the blade channel to ensure there isn’t any drag on the blade when you are opening and closing it. The patented innovative thumb slide features three ceramic balls to minimize wear on the mechanisms, meaning smoother action for the life of your knife. The RECON is the culmination of years of development and careful craftsmanship of the best machinists and technicians in the business. Our favorite Guardian Tactical OTF model is the RECON. The unique design minimizes blade friction for easy deployment and superior performance. Guardian Tactical OTF knives have the smoothest and quickest double-action opening mechanism on the market. Guardian Tactical designers work closely with professionals to create OTF knives that are versatile for a range of real-world applications. But what the company lacks in industry experience, they make up for with outstanding craftsmanship. The durable construction is made to withstand hard use, and the refined aesthetic makes it a knife worthy of any knife collection.ĭue to its popularity, Benchmade released several editions of the Infidel, including the Mini Infidel with a 3.1-inch blade, making it the ideal OTF knife for EDC.Īs one of the more recent companies to start producingOTF knives in the States, Guardian Tactical OTF knives have made a big impression on the knife industry. The construction is a feat of engineering perfection, with a 3.9-inch D2 stainless steel blade and 5-inch black aluminum handle that features the thumb slider on the cover. ![]() The Benchmade Infidel is the King of OTF knives. Their use of different grades of steel enables them to create collections of knives suited explicitly to different demographics, with their Black Class blades constructed from heavy-duty materials ideal for law enforcement and their Blue Class offering Benchmade’s quality construction at a price affordable for everyday carriers. The Benchmade line of OTF knives features their patented Axis lock mechanism, which redefined OTF knife deployment, allowing for use by left- and right-handed carriers and offering the strongest locking action on the market. The blade is a 3.75-inch Vegas Forge Damascus steel with an intricate “Vines Roses” pattern, while the 5.2-inch black hefted alloy handle features blue accents and the thumb slider built into the front of the handle.īenchmade has gained a fiercely loyal following in the knife industry, thanks to their groundbreaking approach to design. One of the limited-edition knives available from the Marfione Custom collection is the custom Dirac Delta. Their knives are constructed only from the highest-quality luxury materials like brass, copper, and Damascus steel, and all components are machined and assembled in-house. Marfione Custom Knives is a division of Microtech dedicated to pushing the limit of knife design and capabilities. ![]() If you could only have one OTF knife in your collection, then an OTF knife from Marfione Custom Knives is a great choice. With a 3.44-inch drop point blade and T6 aluminum handle, the Ultratech is the perfect blend of form and functionality, with a size and weight that make it perfect for EDC. The Microtech Ultratech has appealed to knife enthusiasts across the globe since its release in 1999. The current OTF knife models from Microtech include Halo 6, Combat Troodon, Troodon, Ultratech, UTX-85, UTX-70, and two new models, Dirac and Dirac Delta. Microtech OTF knives are 100% American made and are the knife of choice for law enforcement and military professionals, as well as everyday carriers and collectors, due to their durability, reliability, and smooth double-action deployment mechanism. Over the last 20 years, Anthony Marfione has taken Microtech from a small custom knife business to one of the leading brands in the industry, due to his constant innovation and impeccable workmanship. Here are 4 favorite OTF knife brands to add to your collection. With a double action mechanism for quick deployment and retraction, OTF knives have always been the go-to knife for law enforcement, military professionals, and first responders. ![]() There, Greenblatt argued that More was under the Epicurean influence of Lucretius's On the Nature of Things and the people that live in Utopia were an example of how pleasure has become their guiding principle of life. Quentin Skinner's interpretation of Utopia is consistent with the speculation that Stephen Greenblatt made in The Swerve: How the World Became Modern. But without communism, which he saw no possibility of occurring, it was wiser to take a more pragmatic view. Thus the society Raphael proposes is the ideal More would want. Crucially, Skinner sees Raphael Hythlodaeus as embodying the Platonic view that philosophers should not get involved in politics, while the character of More embodies the more pragmatic Ciceronian view. He has argued that More was taking part in the Renaissance humanist debate over true nobility, and that he was writing to prove the perfect commonwealth could not occur with private property. One highly influential interpretation of Utopia is that of intellectual historian Quentin Skinner. It can be answered, however, that as a pagan society Utopians had the best ethics that could be reached through reason alone, or that More changed from his early life to his later when he was Lord Chancellor. Similarly, the criticism of lawyers comes from a writer who, as Lord Chancellor, was arguably the most influential lawyer in England. Another often cited apparent contradiction is that of the religious tolerance of Utopia contrasted with his persecution of Protestants as Lord Chancellor. Yet, the puzzle is that some of the practices and institutions of the Utopians, such as the ease of divorce, euthanasia and both married priests and female priests, seem to be polar opposites of More's beliefs and the teachings of the Catholic Church of which he was a devout member. Indeed, Utopia has many of the characteristics of satire, and there are many jokes and satirical asides such as how honest people are in Europe, but these are usually contrasted with the simple, uncomplicated society of the Utopians. Most scholars see it as a comment on or criticism of 16th century Catholicism, for the evils of More's day are laid out in Book I and in many ways apparently solved in Book II. One of the most troublesome questions about Utopia is Thomas More's reason for writing it. Many aspects of More's description of Utopia are reminiscent of life in monasteries. The book is a frame narrative primarily depicting a fictional island society and its religious, social and political customs. Utopia (Libellus vere aureus, nec minus salutaris quam festivus, de optimo rei publicae statu deque nova insula Utopia) is a work of fiction and socio-political satire by Thomas More (1478-1535) published in 1516 in Latin. However, in standard usage, the word's meaning has narrowed and now usually describes a non-existent society that is intended to be viewed as considerably better than contemporary society. The word comes from Greek and strictly describes any non-existent society 'described in considerable detail'. The term utopia was coined from Greek by Sir Thomas More for his 1516 book Utopia, describing a fictional island society in the south Atlantic Ocean off the coast of South America. To learn more about how and for what purposes Amazon uses personal information (such as Amazon Store order history), please visit our Privacy notice. You can change your choices at any time by visiting Cookie preferences, as described in the Cookie notice. Click "Decline" to reject, or "Customise" to make more detailed advertising choices, or learn more. The 103 third parties who use cookies on this service do so for their purposes of displaying and measuring personalized ads, generating audience insights, and developing and improving products. Cookies store or access standard device information such as a unique identifier. Your choice applies to using first-party and third-party advertising cookies on this service. If you agree, we'll also use cookies to complement your shopping experience across the Amazon stores as described in our Cookie notice. We also use these cookies to understand how customers use our services (for example, by measuring site visits) so we can make improvements. We use cookies and similar tools that are necessary to enable you to make purchases, to enhance your shopping experiences and to provide our services, as detailed in our Cookie notice. ![]() Instead, I shall develop a consensus about how mitochondria produce ROS and indicate current uncertainties and future issues to be addressed. Since then, a huge literature has developed on the sources and consequences of mitochondrial ROS production, which I will not attempt to cover systematically. The parallel discovery that mitochondria contain their own SOD (superoxide dismutase), MnSOD, confirmed the biological significance of mitochondrial O 2 Later, it was confirmed that this H 2O 2 arose from the dismutation of superoxide (O 2 The first report that the respiratory chain produced ROS came in 1966, followed by the pioneering work of Chance and colleagues who showed that isolated mitochondria produce H 2O 2. Consequently, knowledge of how mitochondria produce ROS is vital to understand a range of currently important biomedical topics ( Figure 1). This ROS production contributes to mitochondrial damage in a range of pathologies and is also important in redox signalling from the organelle to the rest of the cell. Mitochondria are an important source of ROS (reactive oxygen species) within most mammalian cells. − and H 2O 2 formation in vivo, as uncertainty about these values hampers studies on the role of mitochondrial ROS in pathological oxidative damage and redox signalling.There is a clear need to develop better methods to measure mitochondrial O 2 Even so, the description outlined here facilitates the understanding of factors that favour mitochondrial ROS production. −-production rates by isolated mitochondria, and such extrapolations in the literature are misleading.− generation by mitochondria in vivo from O 2.Consequently, it is not possible to estimate O 2 ![]() − within the mitochondrial matrix depends critically on Δp, the NADH/NAD + and CoQH 2/CoQ ratios and the local O 2 concentration, which are all highly variable and difficult to measure in vivo.For mitochondria that are actively making ATP, and consequently have a lower Δp and NADH/NAD + ratio, the extent of O 2 − production, predominantly from complex I: (i) when the mitochondria are not making ATP and consequently have a high Δp (protonmotive force) and a reduced CoQ (coenzyme Q) pool and (ii) when there is a high NADH/NAD + ratio in the mitochondrial matrix.Two modes of operation by isolated mitochondria result in significant O 2 − is related to the concentration of potential electron donors, the local concentration of O 2 and the second-order rate constants for the reactions between them.− production within the matrix of mammalian mitochondria.−) is the proximal mitochondrial ROS, and in the present review I outline the principles that govern O 2.The production of ROS (reactive oxygen species) by mammalian mitochondria is important because it underlies oxidative damage in many pathologies and contributes to retrograde redox signalling from the organelle to the cytosol and nucleus. |
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